Progesterone (Prescription)
What is it? Overview Usage Side Effects and Warnings

Progesterone (Prescription) Overview

Written by FoundHealth.

(proe JES ter one)

U.S. Brand Names

Crinone®; Endometrin®; First™-Progesterone VGS; Prochieve®; Prometrium®

Canadian Brand Names

Crinone®; Prometrium®

Mexican Brand Names

Gepromi; Geslutin; Utrogestan

Pharmacologic Category


What key warnings should I know about before taking this medicine?

• Do not take with estrogens to prevent heart disease or dementia. Using estrogens may increase your chances of having a heart attack, a stroke, breast cancer, or a blood clot.

• This medicine does not mix well with some medicines. Serious reactions may occur. Check all medicines with healthcare provider.

Reasons not to take this medicine

• If you have an allergy to progesterone or any other part of this medicine.

• If you have a peanut allergy and are taking the capsules. The capsules contain peanut oil.

• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.

• If you have any of the following conditions: Bleeding into the brain, blood clots, breast cancer, heart attack, liver disease, stroke, or unexplained vaginal bleeding.


• If you are pregnant or may be pregnant.

How does it work?

• Progestins are produced by the body and are used for development of milk-producing glands and maintenance of the menstrual cycle.

• It maintains pregnancy.

How is it best taken?


• Follow directions given by healthcare provider or read the package insert.

• Take this medicine with or without food. Take with food if it causes an upset stomach.


• This medicine is given as a shot into a muscle.


• Use gel vaginally.

• Use tablet vaginally.

What do I do if I miss a dose? (does not apply to patients in the hospital)

• Take a missed dose as soon as possible.

• If it is almost time for the next dose, skip the missed dose and return to your regular schedule.

• Do not take a double dose or extra doses.

What should I monitor?

• Change in condition being treated. Is it better, worse, or about the same?

• Periodic breast (monthly self-exam) and regular breast and gynecologic exams are important.

• Follow up with healthcare provider.

How should I store this medicine?

• Store at room temperature.

• Protect capsules from moisture. Do not store in a bathroom or kitchen.

General statements

• If you have a life-threatening allergy, wear allergy identification at all times.

• Do not share your medicine with others and do not take anyone else's medicine.

• Keep all medicine out of the reach of children and pets.

• Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.

• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).

• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.

• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.

Created: 2005-04-07 17:12:49.0

Modified: 2010-03-09 08:26:57.0

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