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What is it? Overview Usage Side Effects and Warnings

Promethazine Overview

Written by FoundHealth.

(proe METH a zeen)

U.S. Brand Names

Phenadoz™; Phenergan®; Promethegan™

Canadian Brand Names

Bioniche Promethazine; Histantil; Phenergan®; PMS-Promethazine

Pharmacologic Category

Antiemetic; Histamine H1 Antagonist; Histamine H1 Antagonist, First Generation

What key warnings should I know about before taking this medicine?

• Talk with healthcare provider before giving this medicine to a child. Check all of your child's medicines, including over-the-counter, with healthcare provider.

• This medicine does not mix well with some medicines. Serious reactions may occur. Check all medicines with healthcare provider.


• This medicine may irritate or damage the vein.

Reasons not to take this medicine

• Do not give this medicine to a child younger than 2 years of age.

• If you have an allergy to promethazine or any other part of this medicine.

• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.

• If you have any of the following conditions: Asthma or lung disease.

How does it work?

• Promethazine blocks the allergic reaction by minimizing or preventing the body's reaction to the allergen.

• It affects the vomiting center in the brain.

• It calms the brain.

How is it best taken?

• Take this medicine 30 to 60 minutes before travel if using for motion sickness.

• Take tablet or liquid (syrup) with food.

• A liquid (syrup) is available if you cannot swallow pills.

• Those who have feeding tubes can also use the liquid. Flush the feeding tube before and after medicine is given.


• Use suppository rectally.

• Remove foil wrapper.

• Insert suppository into the rectum with gentle pressure, pointed end first. Do not handle too much.


• This medicine is given as a shot into a muscle or vein.

What do I do if I miss a dose? (does not apply to patients in the hospital)

• Use a missed dose as soon as possible.

• If it is almost time for the next dose, skip the missed dose and return to your regular schedule.

• Do not use a double dose or extra doses.

• Many times this medicine is taken on an as needed basis.

What should I monitor?

• Change in condition being treated. Is it better, worse, or about the same?

• Dry mouth may cause an increase in cavities. Take good care of your teeth. See a dentist regularly.

How should I store this medicine?

• Store liquid (syrup) and tablets at room temperature.

• Protect liquid (syrup) and tablets from light.

• Protect tablets from moisture. Do not store in a bathroom or kitchen.

• Store suppositories in a refrigerator. Do not freeze.

• The injection will be given to you in a healthcare setting. You will not store it at home.

General statements

• If you have a life-threatening allergy, wear allergy identification at all times.

• Do not share your medicine with others and do not take anyone else's medicine.

• Keep all medicine out of the reach of children and pets.

• Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.

• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).

• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.

• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.

Created: 2006-10-13 15:18:41.0

Modified: 2010-05-05 15:43:51.0

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