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Proteolytic Enzymes
What is it? Overview Usage Side Effects and Warnings

Proteolytic Enzymes Side Effects and Warnings

Written by FoundHealth.

Safety Issues

In studies, proteolytic enzymes are believed to have proven to be quite safe, although they can occasionally cause digestive upset and allergic reactions.

One proteolytic enzyme, pancreatin, may interfere with folate absorption. 1 In addition, the proteolytic enzyme papain might increase the blood-thinning effects of warfarin and possibly other anticoagulants. 2 The proteolytic enzyme bromelain might also cause problems if combined with drugs that thin the blood. In addition, there are concerns that bromelain should not be mixed with sedative drugs. Finally, bromelain may increase blood concentrations of certain antibiotics. For more information, see the full Bromelain article.

Interactions You Should Know About

If you are taking:

  • The proteolytic enzyme pancreatin: You may need extra folate.
  • Warfarin (Coumadin), aspirin , or other drugs that "thin" the blood: You should not take the proteolytic enzymes papain or bromelain except under a doctor's supervision.
  • Sedative drugs: Do not take bromelain, except under a physician's supervision.


  1. Russell RM, Dutta SK, Oaks EV, Rosenberg IH, Giovetti AC. Impairment of folic acid absorption by oral pancreatic extracts. Dig Dis Sci. 25(5):369-73.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements. A 5-year toxicological study (1991-1995). Drug Saf. 17(5):342-56.

1 Comment

Posted 5 years ago

As a diabetic aged 48 and about to start dialysis treatment, can I take a Proteolytic Enzyme. Thanks

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