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Pygeum appears to be essentially nontoxic, both in the short and long term. 1 The most common side effect is mild gastrointestinal distress. However, safety in young children, pregnant or nursing women, or those with severe liver or kidney disease has not been established.
- Bombardelli E, Morazzoni P. Prunus africana (Hook. f.) Kalkm. Fitoterapia. 1997;68:205–218.