What is it? Overview Usage Side Effects and Warnings

Pyruvate Side Effects and Warnings

Written by FoundHealth.

Safety Issues

Both pyruvate and dihydroxyacetone appear to be quite safe, aside from mild side effects, such as occasional stomach upset and diarrhea. Very weak evidence (too weak to get very concerned about) hints that pyruvate supplements might adversely affect cholesterol profile by negating the positive effects of exercise on HDL ("good" cholesterol). 1 Maximum safe dosages for children, women who are pregnant or nursing, or those with liver or kidney disease have not been established.

Keep in mind that if a contaminant were present, even in very small percentages, there could be harmful results due to the enormous doses of pyruvate used. For this reason, you should make sure to use a high-quality product.


  1. Koh-Banerjee PK, Ferreira MP, Greenwood M, Bowden RG, Cowan PN, Almada AL, Kreider RB. Effects of calcium pyruvate supplementation during training on body composition, exercise capacity, and metabolic responses to exercise. Nutrition. 21(3):312-9.


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