Rifampin and Isoniazid Side Effects and Warnings

What are the precautions when taking this medicine?

• If you have diabetes, talk with healthcare provider.

• If you have kidney disease, talk with healthcare provider.

• If you have porphyria, talk with healthcare provider.

• Check medicines with healthcare provider. This medicine may not mix well with other medicines.

• Do not take antacids within 1 hour of this medicine.

• Avoid alcohol (includes wine, beer, and liquor). Alcohol can worsen liver disease.

• Tell healthcare provider if you are pregnant or plan on getting pregnant.

• Birth control pills and other hormone-based birth control may not work to prevent pregnancy. Use another form of birth control while taking this medicine.

• Tell healthcare provider if you are breast-feeding.

What are some possible side effects of this medicine?

• Change in color of body fluids to orange.

• Discoloration of contact lenses. Do not wear while taking this medicine.

• Belly pain.

• Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.

• Diarrhea. Yogurt, Bifidobacterium bifidum, or Lactobacillus acidophilusmay help. These products are available at health food stores or in some pharmacies.

• Feeling dizzy. Rise slowly over several minutes from sitting or lying position. Be careful climbing.

• Liver damage can rarely occur.

Reasons to call healthcare provider immediately

• If you suspect an overdose, call your local poison control center or emergency department immediately.

• Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.

• Severe nausea or vomiting.

• Severe diarrhea, even after medicine is stopped.

• Not able to eat.

• Dark urine or yellow skin or eyes.

• Feeling extremely tired or weak.

• Sudden change in vision, eye pain, or irritation.

• Numbness or tingling of hands or feet.

• Any rash.

• No improvement in condition or feeling worse.