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S-adenosylmethionine, the abbreviation for which is SAMe (pronounced samm-ee), is a chemical structure whose name is derived from two materials: methionine, a sulfur-containing amino acid; and adenosine triphosphate (ATP), the body's main energy molecule.
SAMe is a natural substance produced by the body. It helps to produce mood-elevating brain chemicals, such as dopamine and serotonin. SAMe is an anti-inflammatory and pain reliever.1
SAMe was discovered in Italy in 1952. It was first investigated as a treatment for depression, but along the way it was accidentally noted to improve arthritis symptoms—a kind of positive side effect.
Unfortunately, SAMe is an extraordinarily expensive supplement at present. Full dosages can easily cost more than $200 per month.
S. Glorioso et al. Double-Blind Multicentre Study of the Activity of S-Adenosylmethionine in Hip and Knee Osteoarthritis International Journal of Clinical Pharmacology Research 5 (1985), 39-49