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Sirolimus
What is it? Overview Usage Side Effects and Warnings
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Sirolimus Overview

Written by FoundHealth.

(sir OH li mus)

U.S. Brand Names

Rapamune®

Canadian Brand Names

Rapamune®

Mexican Brand Names

Rapamune

Pharmacologic Category

Immunosuppressant Agent; mTOR Kinase Inhibitor

What key warnings should I know about before taking this medicine?

• Long-term use may increase risk of cancer and serious infections.

• Sirolimus may have serious adverse effects if used for liver or lung transplantation.

• This medicine does not mix well with many medicines. Serious reactions may occur. Check all medicines with healthcare provider.

Reasons not to take this medicine

• If you have an allergy to sirolimus or any other part of this medicine.

• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.

• If you are pregnant or may be pregnant.

• If you are breast-feeding.

How does it work?

• Sirolimus helps the body accept a transplanted organ.

• It decreases the body's harmful response to diseases affecting the immune system.

How is it best taken?

All forms:

• This medicine is used in combination with other medicine to help the body accept the new organ.

• To gain the most benefit, do not miss doses.

• Take this medicine with or without food, but be consistent. Always take with food or always take on an empty stomach.

Oral solution:

• Put 1/4 cup of water or orange juice into a cup.

• Measure the medicine in the oral dose syringe. Empty medicine from syringe into cup. Mix well and drink.

• Fill container again with 1/2 cup of water or orange juice. Mix well and drink.

Tablet:

• Swallow whole. Do not chew, break, or crush.

What do I do if I miss a dose? (does not apply to patients in the hospital)

• Take a missed dose as soon as possible.

• If it is almost time for the next dose, skip the missed dose and return to your regular schedule.

• Do not take a double dose or extra doses.

• Do not change dose or stop medicine. Talk with healthcare provider.

What should I monitor?

• Change in condition being treated. Is it better, worse, or about the same?

• Check blood work regularly. Talk with healthcare provider.

• Check blood pressure and heart rate regularly. Talk with healthcare provider.

How should I store this medicine?

• Store tablets at room temperature.

• Protect liquid (solution) and tablets from light.

• Protect tablets from moisture. Do not store in a bathroom or kitchen.

• Store liquid (solution) at room temperature or in a refrigerator. Throw away any unused portion after 15 days if stored at room temperature. Throw away any unused portion after 1 month if refrigerated.

• Liquid (solution) may look hazy when refrigerated. Bring to room temperature and shake gently until haze goes away.

• Store liquid (solution) in a syringe at room temperature for 24 hours.

General statements

• If you have a life-threatening allergy, wear allergy identification at all times.

• Do not share your medicine with others and do not take anyone else's medicine.

• Keep all medicine out of the reach of children and pets.

• Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.

• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).

• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.

• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.

Created: 2006-10-13 15:40:50.0

Modified: 2010-03-26 10:46:54.0

Lexi-PALS TM © (1977)-(2007) Lexi-Comp, Inc. All rights reserved.

 
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