Find us on Social Media:

What is it? Overview Usage Side Effects and Warnings

Sirolimus Overview

Written by FoundHealth.

(sir OH li mus)

U.S. Brand Names


Canadian Brand Names


Mexican Brand Names


Pharmacologic Category

Immunosuppressant Agent; mTOR Kinase Inhibitor

What key warnings should I know about before taking this medicine?

• Long-term use may increase risk of cancer and serious infections.

• Sirolimus may have serious adverse effects if used for liver or lung transplantation.

• This medicine does not mix well with many medicines. Serious reactions may occur. Check all medicines with healthcare provider.

Reasons not to take this medicine

• If you have an allergy to sirolimus or any other part of this medicine.

• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.

• If you are pregnant or may be pregnant.

• If you are breast-feeding.

How does it work?

• Sirolimus helps the body accept a transplanted organ.

• It decreases the body's harmful response to diseases affecting the immune system.

How is it best taken?

All forms:

• This medicine is used in combination with other medicine to help the body accept the new organ.

• To gain the most benefit, do not miss doses.

• Take this medicine with or without food, but be consistent. Always take with food or always take on an empty stomach.

Oral solution:

• Put 1/4 cup of water or orange juice into a cup.

• Measure the medicine in the oral dose syringe. Empty medicine from syringe into cup. Mix well and drink.

• Fill container again with 1/2 cup of water or orange juice. Mix well and drink.


• Swallow whole. Do not chew, break, or crush.

What do I do if I miss a dose? (does not apply to patients in the hospital)

• Take a missed dose as soon as possible.

• If it is almost time for the next dose, skip the missed dose and return to your regular schedule.

• Do not take a double dose or extra doses.

• Do not change dose or stop medicine. Talk with healthcare provider.

What should I monitor?

• Change in condition being treated. Is it better, worse, or about the same?

• Check blood work regularly. Talk with healthcare provider.

• Check blood pressure and heart rate regularly. Talk with healthcare provider.

How should I store this medicine?

• Store tablets at room temperature.

• Protect liquid (solution) and tablets from light.

• Protect tablets from moisture. Do not store in a bathroom or kitchen.

• Store liquid (solution) at room temperature or in a refrigerator. Throw away any unused portion after 15 days if stored at room temperature. Throw away any unused portion after 1 month if refrigerated.

• Liquid (solution) may look hazy when refrigerated. Bring to room temperature and shake gently until haze goes away.

• Store liquid (solution) in a syringe at room temperature for 24 hours.

General statements

• If you have a life-threatening allergy, wear allergy identification at all times.

• Do not share your medicine with others and do not take anyone else's medicine.

• Keep all medicine out of the reach of children and pets.

• Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.

• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).

• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.

• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.

Created: 2006-10-13 15:40:50.0

Modified: 2010-03-26 10:46:54.0

Lexi-PALS TM © (1977)-(2007) Lexi-Comp, Inc. All rights reserved.



No one has made any comments yet. Be the first!

Your Comment