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What are the precautions when taking this medicine?
• Do not take St John's wort with this medicine. It may make this medicine less effective.
• If you have heart disease, talk with healthcare provider.
• If you have had a recent heart attack, talk with healthcare provider.
• If you have high blood pressure, talk with healthcare provider.
• If you have liver disease, talk with healthcare provider.
• If you are having surgery, talk with healthcare provider.
• Check medicines with healthcare provider. This medicine may not mix well with other medicines.
• Talk with healthcare provider before receiving any vaccinations. Use with this medicine may either increase the risk of serious infection or make the vaccination less effective.
• Talk with healthcare provider before using other: aspirin, aspirin-containing products, blood thinners, garlic, ginseng, ginkgo, ibuprofen or like products, pain medicines, or vitamin E.
• Use birth control that you can trust to prevent pregnancy while taking this medicine and for at least 2 weeks after treatment ends.
• If you are a male and sexually active, protect your partner from pregnancy. Use birth control that you can trust.
What are some possible side effects of this medicine?
• Feeling tired or weak.
• Swelling or pain of hands or feet.
• High blood pressure.
• Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
• Hair loss. Hair usually grows back when medicine is stopped.
• Not hungry.
• Low white blood cell count or low platelet count.
• Bleeding problems.
• Weight loss.
• Heart disease may rarely occur.
• Holes in the gastrointestinal tract may rarely occur.
Reasons to call healthcare provider immediately
• If you suspect an overdose, call your local poison control center or emergency department immediately.
• Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
• Signs or symptoms of infection. These include a fever of 100.5 degrees or higher, chills, severe sore throat, ear or sinus pain, cough, increased sputum or change in color, painful urination, mouth sores, wound that will not heal, or anal itching or pain.
• Significant change in thinking clearly and logically.
• Sudden change in vision.
• Chest pain or pressure.
• Severe headache.
• Severe belly pain.
• Severe nausea or vomiting.
• Severe diarrhea.
• Severe swelling or pain of hands or feet.
• Unusual bruising or bleeding.
• Feeling extremely tired or weak.
• Numbness or tingling of hands or feet.
• Any rash.
• No improvement in condition or feeling worse.