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What is it? Overview Usage Side Effects and Warnings

Tolcapone Overview

Written by FoundHealth.

(TOLE ka pone)

U.S. Brand Names


Mexican Brand Names


Pharmacologic Category

Anti-Parkinson's Agent, COMT Inhibitor

What key warnings should I know about before taking this medicine?

• This medicine may cause liver problems. Blood tests will be needed to watch for any liver problems. They will be done before you start taking this medicine and every 2 weeks during treatment. If you had liver changes from this medicine in the past, do not use this medicine again. Signs of liver problems include dark urine, feeling tired, not hungry, nausea, vomiting, or yellowing of the skin or eyes. Call healthcare provider right away if you have any of these symptoms.

Reasons not to take this medicine

• If you have an allergy to tolcapone or any other part of this medicine.

• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.

• If you are taking monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine) talk with healthcare provider. Taking the two together could cause dangerously high blood pressure.

How does it work?

• Tolcapone increases levodopa in the brain.

How is it best taken?

• Take this medicine with or without food. Take with food if it causes an upset stomach.

What do I do if I miss a dose? (does not apply to patients in the hospital)

• Take a missed dose as soon as possible.

• If it is almost time for the next dose, skip the missed dose and return to your regular schedule.

• Do not take a double dose or extra doses.

• Do not change dose or stop medicine. Talk with healthcare provider.

What should I monitor?

• Change in condition being treated. Is it better, worse, or about the same?

• If you are taking a blood thinner, check blood work (prothrombin time/INR). Talk with healthcare provider.

• Keep a diary of your symptoms.

• Check blood work (liver function). Talk with healthcare provider.

• Follow up with healthcare provider.

How should I store this medicine?

• Store at room temperature.

• Protect from moisture. Do not store in a bathroom or kitchen.

General statements

• If you have a life-threatening allergy, wear allergy identification at all times.

• Do not share your medicine with others and do not take anyone else's medicine.

• Keep all medicine out of the reach of children and pets.

• Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.

• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).

• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.

• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.

Created: 2006-10-13 16:04:24.0

Modified: 2010-03-22 11:08:01.0

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