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Tositumomab and Iodine I 131 Tositumomab
What is it? Overview Usage Side Effects and Warnings

Tositumomab and Iodine I 131 Tositumomab Overview

Written by FoundHealth.

(toe si TYOO mo mab & EYE oh dyne eye one THUR tee one toe si TYOO mo mab)

U.S. Brand Names


Pharmacologic Category

Antineoplastic Agent, Monoclonal Antibody; Radiopharmaceutical

What key warnings should I know about before taking this medicine?

• Some patients experience severe reactions during the infusion. This medicine causes low blood cell counts for a long period of time. Your healthcare provider will need to monitor your blood cell counts.

• Do not take this medicine if you are pregnant. Use during pregnancy can cause birth defects. If you become pregnant or plan on getting pregnant while taking this medicine, call healthcare provider right away.

• This medicine does not mix well with many medicines. Serious reactions may occur. Check all medicines with healthcare provider.

Reasons not to take this medicine

• If you have an allergy to tositumomab, iodine, or any other part of this medicine.

• If you are allergic to mouse proteins, talk with healthcare provider.

• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.

• If you are pregnant or may be pregnant.

• If you are breast-feeding.

How does it work?

• Tositumomab injures cancer cells causing their death.

How is it best taken?

• This medicine is given into a vein constantly for a period of time.

• Acetaminophen and diphenhydramine will be given 1 hour before this medicine to decrease fever and chills.

• Medicine to protect the thyroid gland will be given 24 hours before this medicine.

What do I do if I miss a dose? (does not apply to patients in the hospital)

• Call healthcare provider for instructions.

What should I monitor?

• Change in condition being treated. Is it better, worse, or about the same?

• Check blood work regularly. Talk with healthcare provider.

• Watch for tarry black stools.

• Follow up with healthcare provider.

How should I store this medicine?

• This medicine will be given to you in a healthcare setting. You will not store it at home.

General statements

• If you have a life-threatening allergy, wear allergy identification at all times.

• Do not share your medicine with others and do not take anyone else's medicine.

• Keep all medicine out of the reach of children and pets.

• Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.

• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).

• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.

• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.

Created: 2005-04-07 17:24:20.0

Modified: 2010-03-09 08:21:34.0

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