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In the second study mentioned above, tylophora caused nausea, vomiting, mouth soreness, and alterations in taste sensation in more than half of the participants. The other two studies found similar side effects, but far less frequently. The difference may have been because the second study had people chew the whole leaves from the plant, whereas other studies have used dried leaves or powdered extract in capsule form.
Preliminary studies on animals have found tylophora extracts to be toxic only in extremely high doses; these extracts were apparently safe in the far smaller doses needed to produce a therapeutic effect. 1 Due to the lack of comprehensive safety studies on tylophora, the herb should not be used by children, pregnant or nursing women, or individuals with severe kidney or liver disease. Whether tylophora interacts with any drugs is unknown.
- Dikshith TS, Raizada RB, Mulchandani NB. Toxicity of pure alkaloid of Tylophora asthamatica in male rat. Indian J Exp Biol. 28(3):208-12.