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Usages
Effect of Vitamin B1 on Congestive Heart Failure (CHF)
Every cell in your body needs vitamin B1 to make adenosine triphosphate, or ATP, the body's main energy-carrying molecule. The heart, in particular, has considerable need for vitamin B1 in order to...
Read more about Congestive Heart Failure (CHF) and Thiamin.
Therapeutic Uses
Congestive heart failure (CHF) is a condition in which the pumping ability of the heart declines, and fluid begins to accumulate in the lungs and legs. Standard treatment for CHF includes strong "water pills" called loop diuretics . These drugs, however, deplete the body of B 1 . 1 Since the heart depends on vitamin B 1 for its proper function, this is potentially quite worrisome. Preliminary evidence, including a small double-blind placebo-controlled trial , hints that supplementation with B 1 can improve symptoms. 2 One double-blind study suggests that thiamin taken at a dose of 50 mg daily might enhance mental function . 3 Other potential uses of thiamin have even less scientific support. Observational studies of people with HIV infection suggest (but definitely do not prove) that increased intake of vitamin B 1 might slow progression to AIDS and enhance overall survival rate. 4 Weak and contradictory evidence hints that vitamin B 1 may be helpful for Alzheimer's disease . 5 6 7 8 Vitamin B 1 has also been proposed as a treatment for epilepsy , canker sores , and fibromyalgia , but the evidence for these uses is too preliminary to cite.
References
- Brady JA, Rock CL, Horneffer MR. Thiamin status, diuretic medications, and the management of congestive heart failure. J Am Diet Assoc. 95(5):541-4.
- Shimon I, Almog S, Vered Z, Seligmann H, Shefi M, Peleg E, Rosenthal T, Motro M, Halkin H, Ezra D. Improved left ventricular function after thiamine supplementation in patients with congestive heart failure receiving long-term furosemide therapy. Am J Med. 98(5):485-90.
- Benton D, Griffiths R, Haller J. Thiamine supplementation mood and cognitive functioning. Psychopharmacology (Berl). 129(1):66-71.
- Tang AM, Graham NM, Saah AJ. Effects of micronutrient intake on survival in human immunodeficiency virus type 1 infection. Am JEpidemiol. 1996;143:1244-1256.
- Gold M, Hauser RA, Chen MF. Plasma thiamine deficiency associated with Alzheimer's disease but not Parkinson's disease. Metab Brain Dis. 1998;13:43-53.
- Bettendorff L, Mastrogiacomo F, Wins P, Kish SJ, Grisar T, Ball MJ. Low thiamine diphosphate levels in brains of patients with frontal lobe degeneration of the non-Alzheimer's type. J Neurochem. 69(5):2005-10.
- Mimori Y, Katsuoka H, Nakamura S. Thiamine therapy in Alzheimer's disease. Metab Brain Dis. 11(1):89-94.
- Meador K, Loring D, Nichols M, Zamrini E, Rivner M, Posas H, Thompson E, Moore E. Preliminary findings of high-dose thiamine in dementia of Alzheimer's type. J Geriatr Psychiatry Neurol. 6(4):222-9.
