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Vitamin B12
What is it? Overview Usage Side Effects and Warnings

Vitamin B12 Side Effects and Warnings

Written by FoundHealth.

Safety Issues

Vitamin B 12 appears to be extremely safe. However, in some cases very high doses of the vitamin can cause or worsen acne symptoms. 1

Interactions You Should Know About

If you are taking:

Colchicine , AZT , medications that reduce stomach acid (such as the H2 blocker ranitidine [Zantac] or the proton pump inhibitor omeprazole [Prilosec], oral hypoglycemics (such as metformin or phenformin), slow-release potassium supplements, or if you are exposed to nitrous oxide anesthesia: You may need extra B 12 . Another option is to take extra calcium , which may, in turn, improve B 12 absorption.


  1. Sheretz EF. Acneform eruption due to megadose vitamins B 6 and B 12. Cutis.. 1991;48:19-20.


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