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Preliminary evidence suggests that riboflavin supplements taken at high dosages may reduce the frequency of migraine headaches . 1 One very large study suggests that riboflavin at nutritional doses may be helpful for cataracts , but in this study it was combined with another B vitamin—niacin ( vitamin B 3 )—so it's hard to say which vitamin was responsible for the effect. 2 Riboflavin has also been proposed as a treatment for sickle-cell anemia , 3 HIV infection, 4 and as a performance enhancer for athletes, but there is no real evidence that it is effective for these uses.
- Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology. 50(2):466-70.
- Sperduto RD, Hu TS, Milton RC, et al. The Linxian cataract studies. Two nutrition intervention trials. Arch Ophthalmol. 1993;111:1246-1253.
- Ajayi OA, George BO, Ipadeola T. Clinical trial of riboflavin in sickle cell disease. East Afr Med J. 70(7):418-21.
- Tang AM, Graham NM, Saah AJ. Effects of micronutrient intake on survival in human immunodeficiency virus type 1 infection. Am JEpidemiol. 1996;143:1244-1256.